Name | 3,5,6,7,8,3',4'-heptemthoxyflavone |
Synonyms | NSC 618928 3-Methoxynobiletin 5,6,7,8,3,4-hepteMthoxyflavone 3,5,6,7,8,3',4'-heptemthoxyflavone 3,5,6,7,8,3',4'-hepteMthoxyflavone 3,3',4',5,6,7,8-heptamethoxyflavone 3',4',3,5,6,7,8-Heptamethoxyflavone 2-(3,4-Dimethoxyphenyl)-3,5,6,7,8-pentamethoxy-4H-chromen-4-one 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxy- |
CAS | 1178-24-1 |
Molecular Formula | C22H24O9 |
Molar Mass | 432.42 |
Density | 1.31±0.1 g/cm3(Predicted) |
Melting Point | 129-131 °C |
Boling Point | 618.7±55.0 °C(Predicted) |
Solubility | Almost insoluble (0.052g/L) (25°C), |
Appearance | Pale yellow powder |
Storage Condition | 2-8℃ |
MDL | MFCD00210513 |
Physical and Chemical Properties | Pale yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Fructus Aurantii Immaturus. |
Reference Show more | 1. Gao Xi-Mei, Wang Xiao, Feng, Zhou Bing-Qian, et al. Establishment of HPLC fingerprint of pericarpium citri reticulatae under multi-wavelength conditions and "one test and multiple evaluation" method [J]. Chinese herbal medicine, 42 Vol. 11 page 2598-2602 MEDLINE microscopic PKU 2020. 2. Zhou Qi, talk about anqun, Yi Xin, etc. Identification of broad-peel orange juice from orange juice based on characteristic components of citrus juice polymethoxyflavone [J]. Food and Fermentation Industry, 2019, 45:227-233. 3. Simultaneous determination of 12 kinds of methoxyflavonoids and coumarins in citrus juice by Li Guijie, Tan Xiang, Wang Hua, Wu Houyan, Russell ROUSEFF.HPLC-DAD-FLD [J]. Food Science, 2017, 38(20):112-118. 4. Feng, Konglong, et al. "Hepatic lipidomics analysis reveals the antiobesity and cholesterol-lowering effects of tangeretin in high-fat diet-fed rats." Journal of agricultural and food chemistry 68.22 (2020): 6142-6153.https://doi.org/10.1021/acs.jafc.0c017 5. Wang, Peng, et al. "Chemical and genetic discrimination of commercial Guangchenpi (Citrus reticulata 'Chachi') by using UPLC-QTOF-MS/MS based metabolomics and DNA barcoding approaches." RSC advances 9.40 (2019): 23373-23381.https://doi.org/10.1039/C9RA0374 6. [IF=5.279] Wei-Lun Hung et al."A Targeted Mass Spectrometry-Based Metabolomics Approach toward the Understanding of Host Responses to Huanglongbing Disease."J Agr Food Chem. 2018;66(40):10651-10661 7. [IF=7.132] Li Yang et al."Supercritical extraction and antioxidant activity of major ingredients in Puerariae lobatae root, Pinus massoniana needle, Citrus reticulata peel and their mixture."J Co2 Util. 2021 Jun;48:101518 8. [IF=5.279] Linhua Huang et al."Effects of Scion/Rootstock Combination on Flavor Quality of Orange Juice from Huanglongbing (HLB)-Affected Trees: A Two-Year Study of the Targeted Metabolomics."J Agr Food Chem. 2020;68(10):3286-3296 9. [IF=5.279] Konglong Feng et al."Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats."J Agr Food Chem. 2020;68(22):6142-6153 10. [IF=4.162] Guijie Li et al."Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil."Drug Des Dev Ther. 2021; 15: 937-947 11. [IF=2.629] Mu Qixuan et al."Study on Closely Related Citrus CMMs based on Chemometrics and Prediction of Components-Targets-Diseases Network by Ingenuity Pathway Analysis."Evid-Based Compl Alt. 2022;2022:1106353 12. [IF=6.576] Mei Yang et al."Chemical Variation of Chenpi (Citrus Peels) and Corresponding Correlated Bioactive Compounds by LC-MS Metabolomics and Multibioassay Analysis."Front Nutr. 2022; 9: 825381 13. [IF=4.35] Qian Yu et al."Aged Pericarpium Citri Reticulatae 'Chachi' Attenuates Oxidative Damage Induced by tert-Butyl Hydroperoxide (t-BHP) in HepG2 Cells."Foods. 2022 Jan;11(3):273 |
biological activity | 3,5,6,7,8,3 ',4'-Heptemthoxyflavone is a flavone in mandarin peel, which has anti-tumor initial activity and anti-neuroinflammatory activity. 3,5,6,7,8,3 ',4'-Heptemthoxyflavone can inhibit the activity of collagenase and increase the content of type I procollagen in human dermal fibroblasts (HDFn) cells. 3,5,6,7,8,3 ',4'-Heptemthoxyflavone can induce brain-derived neurotrophic factor (BDNF) expression through cAMP/ERK/CREB signal and reduce phosphodiesterase activity in C6 cells. |
chemical properties | light yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from bitter orange. |
use | used for content determination/identification/pharmacological experiments, etc. |